Patient-specific Electrical Stimulation to Effectively Suppress Seizures Using a Data-driven Dynamical Network Model

Session

Description: : This session explores cutting-edge advances in stimulation waveform design across three major neuromodulation modalities: peripheral nerve stimulation, spinal cord stimulation, and deep brain stimulation. As the field evolves beyond conventional rectangular pulses, novel temporal patterns and waveform shapes are demonstrating enhanced therapeutic efficacy, improved selectivity, and reduced energy consumption. Leading researchers will present their work on innovative approaches including amplitude-modulated high-frequency stimulation for desynchronized yet controllable neural firing in peripheral nerves, computational modeling for optimal temporal pattern design in deep brain stimulation, and dynamic pulse patterns in spinal cord stimulation that expand paresthesia coverage and sensation quality. The session will examine how these waveform innovations fundamentally alter neural recruitment patterns, potentially enabling more precise targeting of specific neural populations while avoiding unwanted activation. Presentations will cover computational modeling approaches that predict neural responses to complex waveforms, preclinical evidence demonstrating physiological effects, and emerging clinical applications. By bringing together experts from different stimulation modalities, this session aims to identify common principles and challenges in waveform design that span different therapeutic applications, fostering cross-pollination of ideas that could accelerate innovation in this rapidly evolving field.