Deep Brain Stimulation for Alzheimer’s Disease in Non-human Primates

Session

Description: The prevalence of neurodegenerative diseases, specifically Alzheimer's disease, is on the rise in the US and the amyloid hypothesis is steeped in controversy. Therefore, there is a need for innovative approaches to treating Alzheimer's disease – and neuromodulation may be the answer. This session will investigate the potential of both invasive and non-invasive neuromodulation in modifying disease progression, enhancing cognitive function, and improving patient outcomes. Technologies such as deep brain stimulation and transcranial magnetic stimulation will be analyzed. Furthermore, different possible targets such as the nucleus basalis of Meynert and the Fornix will be compared. Discussions will cover mechanisms of action, recent clinical trials, and the challenges in bringing the technologies into clinic. By bringing together experts from diverse fields, this session aims to facilitate interdisciplinary collaboration and drive progress in neuromodulation-based interventions for Alzheimer’s disease.