Hemodynamic and Metabolic Responses to Transcranial Photobiomodulation Measured by Functional Near-infrared Spectroscopy

Session

Description: This session explores the rapidly evolving field of light-based neuromodulation and photobiomodulation (PBM) for treating neurological disorders. Recent advances have demonstrated that specific wavelengths of light, particularly in the red to near-infrared spectrum (600-1300 nm), can effectively modulate neural activity through non-thermal photochemical mechanisms. Leading researchers will present cutting-edge developments in both transcranial and implantable PBM technologies, highlighting their applications across multiple neurological conditions including Parkinson's disease, traumatic brain injury, and neuropathic pain. Presentations will examine the fundamental cellular mechanisms underlying PBM, alongside novel approaches to selectively inhibit neural activity through optical methods. The session will showcase emerging clinical evidence from pioneering trials using intracranial photobiomodulation for Parkinson's disease, and advanced measurement techniques to quantify hemodynamic and metabolic responses to transcranial photobiomodulation. Speakers will address key challenges including optimizing light delivery parameters, enhancing tissue penetration, and developing appropriate biomarkers to monitor therapeutic efficacy. This session provides a comprehensive overview of light-based neuromodulation technologies that offer unique advantages in spatial and temporal precision while potentially modifying disease progression rather than merely managing symptoms.